PackGene’s model takes advantage of rAAV serotype tropisms to selectively infect specific tissues in mice for generating AAV-hACE2 animal models. AAV infected tissues show continuous and stable expression of the hACE2 protein producing in a simple and time-saving method for new coronavirus-related drug development and research.
Comparison between AAV-hACE2 animal modeling and traditional animal modeling:
Comparison between AAV-hACE2 animal modeling and traditional animal modeling:
AAV-hACE2 animal modeling |
Traditional animal modeling |
|
Production Cycle | Short cycle within 14 days | Over 6 months |
Process | Simple | Complicated steps |
Histotropism | Specific distribution | Wide distribution |
Premade hACE2 AAV
Promoter type | Catalog No. | Promoter and Gene | AAV type |
Universal promoter | AAV-C-1875 | ssAAV.CAG.human ACE2.WPRE.SV40pA | ssAAV |
![AAV AAV](https://www.packgene.com/wp-content/uploads/2023/08/AAV.png)
Injection Method: Intranasal Administration
Recommended Dose: 2×10^11GC/ml, 40μl
Animal Model: 6-8-week-old female BALB/c mice
Journal: Antiviral Research, 2022 (IF=10.103)
Paper Title: Rational design of AAVrh10-vectored ACE2 functional domain to broadly block the cell entry of SARS-CoV-2 variants
DOI: https://doi.org/10.1016/j.antiviral.2022.105383
![](https://www.packgene.com/wp-content/uploads/2023/02/6-1.jpg)
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